PQQ and coenzyme Q10 (CoQ10) are synergistic nutrients that modulate cellular signalling pathways, scavenge oxidative free radicals, and support optimal mitochondrial function. Mitochondrial dysfunction plays a role in a variety of conditions and is thought to be an important factor in age-related decline of cell function.
CoQ10 is well established as a mitochondrial enhancer, which may contribute to the prevention of numerous cardiovascular and neurological conditions. CoQ10 increases the efficiency of mitochondrial ATP production and cellular respiration.
Pyrroloquinoline quinone (PQQ) is a compound known to influence multiple cellular pathways, including the production of nerve growth factor (NGF). Like CoQ10, PQQ has diverse benefits for mitochondrial function. It has been shown to attenuate mitochondrial oxidative stress as well as stimulate mitochondrial biogenesis. It also has neuroprotective properties including protecting against glutamate-induced toxicity, a pathway common in many neurodegenerative diseases. PQQ is considered a novel cofactor with antioxidant and B vitamin-like activity. It is derived from a natural fermentation process to enhance absorption.
Taken together, PQQ and CoQ10 have shown clinical benefits for cognitive performance, such as improving attention and information processing, providing superior mitochondrial support, and exerting cardioprotective effects.